Pellagra is a condition in which a person is not taking niacin or tryptophan. It also occurs when the body does not absorb niacin. It is also known as Vitamin B3 deficiency or nicotinic acid deficiency. Niacin is required for the metabolism of fats, protein, and carbohydrates. It maintains nervous system and control body hormones. It is used to improves heart health by maintaining cholesterol. Tryptophan is an amino acid that makes the protein. If niacin or tryptophan amount alleviate in the body it leads to severe medical disorders that may prove life threatening.


The main symptoms associated with this disease are:

  • Canker sores
  • Irritability
  • Fatigue
  • Abdominal pain
  • Vomiting
  • Aggression
  • Loss of appetite
  • Indigestion
  • Inflamed mucous membrane
  • Depression

When the disease becomes severe the following symptoms may also be observed:

  • Swollen mouth
  • Paresthesia
  • Apathy
  • Dermatitis
  • Oesophagitis
  • Seizures
  • Fatigue
  • disorientation
  • Scaly pigmented rash on skin
  • Depression
  • Headache
  • Stomatitis
  • Dementia
  • Vaginitis
  • Diarrhea
  • Vomiting

Causes of pellagra

This disease is caused by following reasons:

  • Improper niacin and tryptophan containing food
  • Alcoholism
  • Gastrointestinal disorders
  • Anorexia
  • HIV
  • Certain medications
Emma Sage Asked on February 22, 2017 in Disease.
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